Membrane Transport,concept in new Folate Analog Design,Development of Nitrosourea Nucleosiders as Anticancer Agent,Inhibitors of Nucleoside Transport as probes and Drugs.Enztme Activity,Plasma-Activated prodrugs for cancer Chemotherapy,Hypoxic cell as therapy for cancer chemotherapy,Gene Function,DNA Crooslinking Agents,Induction of Tumors cell Differentiation as a Therapeutic approach